Although nepotism is a global issue, its connection to employee attitudes and behaviors is not well understood. Based on social exchange and organizational justice theories, this study examines whether job dissatisfaction mediates the relationship between nepotism and organizational silence. A quantitative approach provided empirical evidence and results from a larger context. A structured questionnaire was used, involving 300 participants from Bangladesh’s banking sector. As expected, the study found a positive relationship between nepotism, job dissatisfaction, and organizational silence. Additionally, job dissatisfaction partly explains the relation between nepotism and organizational silence. The research emphasizes the positive impact of nepotism on organizational silence and offers suggestions to reduce its occurrence in organizations. This is the first study to explore how job dissatisfaction influences the relationship between nepotism and organizational silence in Bangladeshi banks. It also addresses ongoing calls for more research on job dissatisfaction and its causes.